Diabetic Reversal Using Mesenchymal Stem Cells (MSCs) at Regenerative Medical Clinic Mauritius (Dr. Kevin Ramdhun and Team)
Diabetic Reversal Using Mesenchymal Stem Cells (MSCs) at Regenerative Medical Clinic Mauritius (Dr. Kevin Ramdhun and Team) Below is a synthesis of relevant findings and mechanisms from the provided sources: 1. Mechanism of Action: How MSCs Address Diabetes* MSCs are multipotent stromal cells with immunomodulatory, anti-inflammatory, and tissue-repair properties. Their therapeutic potential in diabetes involves: - *β-Cell Regeneration**: MSCs may promote endogenous β-cell proliferation or differentiation into insulin-producing cells, though clinical efficacy remains under investigation . - **Paracrine Effects**: MSCs secrete growth factors (e.g., VEGF, FGF) and cytokines that reduce inflammation, enhance angiogenesis, and protect surviving β-cells . - **Immunomodulation**: In type 1 diabetes, MSCs suppress autoimmune attacks on pancreatic islets by modulating T-cell activity and reducing pro-inflammatory cytokines (e.g., TNF-α, IL-6) . - *...